• Read more about Jeff’s Weight Loss Surgery Success Story

When Jeff's weight started to impact his performances and his health, he turned to Cooper and a team who could help him succeed. Not only was Jeff’s weight affecting his performance, he was beginning to develop serious chronic illnesses

• Read more about SourSop

Short Title: Soursop

The study will determine if there is a reduction in malignant cell burden when patients with relapsed and/or refractory acute myeloid leukemia (AML) or multiple myeloma (MM) consume tea made from the dried leaves of Annona muricata (Soursop). The study goal is to determine the safety and anti-neoplastic efficacy of Annona muricata tea when taken in escalating frequency over a period of 21 days by patients with relapsed/refractory AML or MM for whom there are no standard therapeutic options.

Study Number:

SourSop

Study Status:

Enrolling

Treatment Agent:

Soursop tea

Resources and Links

National Clinical Trial Identified Number: Not available at this time

Disease:

• Acute Myeloid Leukemia ,
• Multiple Myeloma

Study Phase:

Not applicable

researchcancer@cooperhealth.edu

Hide from Search:

Off

Physician Name:

• Roger K. Strair, MD, PhD

Department:

• Hematology and Medical Oncology

• Read more about EA7211 STRASS II

Short Title: STRASS II

This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival.

After confirmation of eligibility criteria, patients will be randomized to either the standard arm or experimental arm.

Standard arm:

• Large en-bloc curative-intent surgery within 4 weeks following randomization- Experimental arm

Experimental arm:

• 3 cycles of neoadjuvant chemotherapy starting within 2 weeks following randomization:

  • High grade LPS: ADM (doxorubicin) 75 mg/m2 (or the equivalent EpiADM 120 mg/m2) + ifosfamide 9 g/m3 Q3 weeks.
  • LMS: ADM 75 mg/m2 + DTIC (dacarbazine) 1 g/m2 Q3 weeks
• re-assessment of operability
• curative-intent surgery within 3-6 weeks of last cycle of chemotherapy

Study Number:

EA7211

Study Status:

Enrolling

Treatment Agent:

Surgery, Preoperative chemotherapy

Resources and Links

National Clinical Trial Identified Number: NCT04031677

Disease:

• Retroperitoneal Sarcoma,
• Liposarcoma,
• Leiomyosarcoma

Study Phase:

III

researchcancer@cooperhealth.edu

Hide from Search:

Off

Physician Name:

• Madeline B. Torres, MD

• Read more about EvoPAR-Breast01

Short Title: EvoPAR-Breast01

The primary objective of the study is to measure efficacy of saruparib (AZD5305) plus camizestrant compared with physician's choice CDK4/6i plus ET in patients with BRCA1, BRCA2, or PALB2m, HR-positive, HER2-negative (defined as IHC 0, 1+, 2+/ ISH non-amplified) advanced breast cancer. 

Participants will be randomised in a 2:2:1 ratio to one of the following intervention groups:

• Arm 1: saruparib (AZD5305) plus camizestrant
• Arm 2: Physician's choice CDK4/6i plus physician's choice ET
• Arm 3: Physician's choice CDK4/6i plus camizestrant Treatment continues until BICR-confirmed disease progression, unacceptable toxicity occurs, or the participant withdraws consent.

Study Number:

EvoPAR-Breast01

Study Status:

Enrolling

Treatment Agent:

Saruparib (AZD5305), Camizestrant, Abemaciclib, Ribociclib, Palbociclib, Fulvestrant, Letrozole, Anastrozole, Exemestane

Resources and Links

National Clinical Trial Identified Number: NCT06380751

Disease:

• Advanced Breast Cancer

Study Phase:

III

researchcancer@cooperhealth.edu

Hide from Search:

Off

Physician Name:

• Rebecca J. Jaslow, MD

Department:

• Hematology and Medical Oncology

• Read more about GY036

Short Title: GY036

This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer. Olaparib is a polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme inhibitor and may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving olaparib for one year with or without bevacizumab may be effective in treating patients with BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer, when compared to two years of olaparib.

Study Number:

GY036

Study Status:

Enrolling

Treatment Agent:

Bevacizumab, Olaparib

Resources and Links

National Clinical Trial Identified Number: NCT06580314

Disease:

• Fallopian Tube Endometrioid Adenocarcinoma,
• Fallopian Tube High Grade Serous Adenocarcinoma,
• Ovarian Carcinoma,
• Ovarian High Grade Endometrioid Adenocarcinoma,
• Ovarian High Grade Serous Adenocarcinoma,
• Primary Peritoneal Endometrioid Adenocarcinoma,
• Primary Peritoneal High Grade Serous Adenocarcinoma

Study Phase:

III

researchcancer@cooperhealth.edu

Hide from Search:

Off

Physician Name:

• David P. Warshal, MD, FACOG

Department:

• Gynecologic Cancer Center